Evans Aldol Reaction

Asymmetric aldol reaction of aldehyde and Evans chiral auxiliary (acyl oxazlidineone).

Highly enantioselective aldol condensation of the chiral N-acyl-oxazolidone via its dibutylboryl enolate with the appropriate aldehyde:

D. A. Evans et al.,J. Am. Chem. Soc.101, 6120 (1979); 103, 2127 (1981).

D. A. Evans et al.,J. Am. Chem. Soc.103, 2127 (1981).

Mechanistic studies:

D. A. Evans et al., J. Am. Chem. Soc. 103, 3099 (1981).

Review:

D. A. Evans, Aldrichim. Acta15, 23-32 (1982).