Mannich reaction

The Mannich reaction involves the reaction between a primary or a secondary amine with an aldehyde and an enolizable carbonyl compound.

Mechanism:

Reviews:

Advances in the Chemistry of Mannich Bases. Maurilio Trammontini Synthesis 1973, 1973(12): 703-775.

Modern variants of the Mannich reaction. Arend, M., Westermann, B., Risch, N.  Angew. Chem., Int. Ed. Engl. 1998, 37, 1045-1070.

The Direct Catalytic Asymmetric Mannich Reaction. Cordova, A.  Acc. Chem. Res. 2004, 37, 102-112.

Recent:

The Direct and Enantioselective, One-Pot, Three-Component, Cross-Mannich Reaction of Aldehydes. Y. Hayashi, W. Tsuboi, I. Ashimine, T. Urushima, M. Shoji, K. Sakai Angew. Chem. Int. Ed. 2003,  42(31), 3677–3680